The protocols for Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), the NIMH-sponsored trials of atypical antipsychotics in schizophrenia and Alzheimer’s disease, are now available and accessible to the field. They can be reached through the clinical trials page of the NIMH Web site at <www.nimh.nih.gov/studies/index.cfm>. Patient enrollment will begin in the fall, while recruitment of clinical sites is ongoing. Interested sites can also find information at this URL address. Comments are invited on all aspects of the study and can be submitted through the Web site.